Literature summary extracted from

Shin, H.C.; Song, M.C.; Scheraga, H.A.
Effect of protein disulfide isomerase on the rate-determining steps of the folding of bovine pancreatic ribonuclease A (2002), FEBS Lett., 521, 77-80.

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.6.1.18	Bos taurus	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
4.6.1.18	additional information	native enzyme contains four intra-molecular disulfide bonds. Protein disulfide isomerase catalyzes the conversion of the kinetically trapped enzyme intermediates, des-[26-84] and des-[58-110], by re-shuffling them into the on-pathway intermediate, des-[40-95], and the formation of the native protein	Bos taurus

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
4.6.1.18	an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]	protein with 124 amino acid residues and four intra-molecular disulfide bonds. In the presence of oxidized and reduced dithiothreitol at pH 8.0 and 25ºC, the enzyme folds through pathways involving a rapid pre-equilibrium resulting in an ensemble of three-disulfide intermediate species. Protein disulfide isomerase catalyzes the conversion of the intermediates to the native enzyme, by acting as both a chaperone and an oxidase on the on-pathway intermediate	Bos taurus	a

Renatured (Commentary)

EC Number	Renatured (Comment)	Organism
4.6.1.18	protein disulfide isomerase acts both as chaperone and an oxidase during the folding of enzyme. Protein disulfide isomerase catalyzes the conversion of the kinetically trapped enzyme intermediates, des-[26-84] and des-[58-110], by re-shuffling them into the on-pathway intermediate, des-[40-95], and the formation of the native protein	Bos taurus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.6.1.18	pancreas	-	Bos taurus	-

Subunits

EC Number	Subunits	Comment	Organism
4.6.1.18	More	protein disulfide isomerase acts both as chaperone and an oxidase during the folding of enzyme. Protein disulfide isomerase catalyzes the conversion of the kinetically trapped enzyme intermediates, des-[26-84] and des-[58-110], by re-shuffling them into the on-pathway intermediate, des-[40-95], and the formation of the native protein	Bos taurus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)